Skin Pharmacology and Physiology· 2016· Clinical trial
Effects of <b><i>Aloe</i></b> Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
- 1,093citations
- 2016year
Short summary
Oral Aloe sterol supplementation for 12 weeks significantly improved skin moisture, elasticity, and collagen content in healthy women compared to a placebo.
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Key points
- 12-week oral Aloe sterol supplementation improved skin moisture and reduced transepidermal water loss.
- Skin elasticity scores (gross, net, and biological) significantly increased in the Aloe sterol group.
- Ultrasound analysis showed increased collagen content in the dermis with Aloe sterol intake.
- The study involved 64 healthy women aged 30-59 years in a placebo-controlled design.
AI-generated from the title and abstract; the full text is not read.
Abstract
<b><i>Background/Aims:</i></b> Our previous study confirmed that <i>Aloe</i> sterol stimulates collagen and hyaluronic acid production in human dermal fibroblasts. This study aims to investigate whether <i>Aloe</i> sterol intake affects skin conditions. <b><i>Methods:</i></b> We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral <i>Aloe</i> sterol supplementation on skin elasticity, hydration, and the collagen score in 64 healthy women (age range 30-59 years; average 44.3 years) who were randomly assigned to receive either a placebo or an <i>Aloe</i> sterol-supplemented yogurt. Skin parameters were measured and ultrasound analysis of the forearm was performed. <b><i>Results:</i></b> ANCOVA revealed statistical differences in skin moisture, transepidermal water loss, skin elasticity, and collagen score between the <i>Aloe</i> sterol and placebo groups. The gross elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores of the <i>Aloe</i> sterol group significantly increased with time. In addition, skin fatigue area F3, which is known to decrease with age and fatigue, also increased with <i>Aloe</i> sterol intake. Ultrasound echogenicity revealed that the collagen content in the dermis increased with <i>Aloe</i> sterol intake. <b><i>Conclusion:</i></b> The results suggest that continued <i>Aloe</i> sterol ingestion contributes to maintaining healthy skin.
The authors' abstract, as published at the source. Skin Pharmacology and Physiology, 2016 · DOI ↗
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Field: Dermatology
DermatologyMedicine