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The FASEB Journal· 2014Q1

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

Christopher S. Reigstad, Charles E. Salmonson, John F. Rainey, Joseph H. Szurszewski et al.

Short summary

Gut microbes significantly increase colonic serotonin production in mice by promoting the expression of Tph1, the rate-limiting enzyme for serotonin synthesis, via short-chain fatty acids acting on enterochromaffin cells.

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Field: Gastroenterology

GastroenterologyMedicine