Science· 2015Q1· Review
NAD <sup>+</sup> in aging, metabolism, and neurodegeneration
- 1,288citations
- Q1SCImago
- 2015year
Short summary
Cellular levels of Nicotinamide adenine dinucleotide (NAD+) decline with age, and manipulating its levels may offer a therapeutic strategy for aging and related disorders, especially neurodegenerative diseases.
AI-generated from the title and abstract; the full text is not read.
Key points
- NAD+ is a critical coenzyme for redox reactions and cellular signaling.
- Cellular NAD+ concentrations decrease with aging.
- Modulating NAD+ levels can potentially extend health span and lifespan.
- NAD+ precursor supplementation is explored as a therapeutic opportunity for aging and neurodegeneration.
AI-generated from the title and abstract; the full text is not read.
Abstract
Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
The authors' abstract, as published at the source. Science, 2015 · DOI ↗
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Field: Geriatrics and Gerontology
Geriatrics and GerontologyMedicine