Antioxidants and Redox Signaling· 2017Q1
NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
- 1,048citations
- Q1SCImago
- 2017year
Short summary
Cellular NAD(H) and NADP(H) pools are compartmentalized and tightly regulated to maintain redox homeostasis and energy metabolism, with potential therapeutic implications for metabolic diseases.
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Key points
- NAD(H) and NADP(H) biosynthesis and distribution are highly compartmentalized within cells.
- Maintaining steady levels of these redox couples is crucial for normal cellular function and preventing redox stress.
- Interactions between NAD(H)/NADP(H)-utilizing enzymes and signaling pathways (e.g., HIF) are key to cellular redox homeostasis and energy metabolism.
- NAD(H) and NADP(H) precursors show potential as therapeutic interventions for metabolic diseases.
AI-generated from the title and abstract; the full text is not read.
Abstract
SIGNIFICANCE: -consuming proteins in regulating cellular redox and metabolic homeostasis are active research topics. CRITICAL ISSUES: The biosynthesis and distribution of cellular NAD(H) and NADP(H) are highly compartmentalized. It is critical to understand how cells maintain the steady levels of these redox couple pools to ensure their normal functions and simultaneously avoid inducing redox stress. In addition, it is essential to understand how NAD(H)- and NADP(H)-utilizing enzymes interact with other signaling pathways, such as those regulated by hypoxia-inducible factor, to maintain cellular redox homeostasis and energy metabolism. FUTURE DIRECTIONS: precursors as therapeutic interventions for metabolic diseases. Thus, a better understanding of the cellular functions of NAD(H) and NADP(H) may facilitate efforts to address a host of pathological disorders effectively. Antioxid. Redox Signal. 28, 251-272.
The authors' abstract, as published at the source. Antioxidants and Redox Signaling, 2017 · DOI ↗
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