Cell Reports· 2013Q1
Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation
- 777citations
- Q1SCImago
- 2013year
Short summary
Lysine succinylation, a post-translational modification, is widespread across bacteria, yeast, human cells, and mouse liver, with a majority of sites overlapping with acetylation.
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Key points
- Lysine succinylation sites were mapped in E. coli, S. cerevisiae, HeLa cells, and mouse liver.
- A majority of succinylation sites in bacteria, yeast, and mouse liver were also acetylated.
- Succinylation levels in yeast are globally influenced by growth conditions and succinyl-CoA metabolism.
- Succinylation preferentially occurs on abundant proteins, suggesting low overall levels.
AI-generated from the title and abstract; the full text is not read.
Abstract
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and mouse liver tissue, demonstrating widespread succinylation in diverse organisms. A majority of succinylation sites in bacteria, yeast, and mouse liver were acetylated at the same position. Quantitative analysis of succinylation in yeast showed that succinylation was globally altered by growth conditions and mutations that affected succinyl-coenzyme A (succinyl-CoA) metabolism in the tricarboxylic acid cycle, indicating that succinylation levels are globally affected by succinyl-CoA concentration. We preferentially detected succinylation on abundant proteins, suggesting that succinylation occurs at a low level and that many succinylation sites remain unidentified. These data provide a systems-wide view of succinylation and its dynamic regulation and show its extensive overlap with acetylation.
The authors' abstract, as published at the source. Cell Reports, 2013 · DOI ↗
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