Blood· 2022Q1· Review
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
- 3,068citations
- Q1SCImago
- 2022year
Short summary
The European LeukemiaNet (ELN) has updated its 2022 recommendations for diagnosing and managing adult acute myeloid leukemia (AML), incorporating recent advances in molecular pathogenesis, genomic diagnostics, and novel therapies.
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Key points
- Updated ELN recommendations for adult AML diagnosis and management released.
- Incorporates new molecular pathogenesis understanding and genomic diagnostic technologies.
- Includes revised ELN genetic risk classification and response criteria.
- Reflects advances in targeted therapies such as FLT3, IDH1/2, and BCL2 inhibitors.
AI-generated from the title and abstract; the full text is not read.
Abstract
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults are widely recognized among physicians and investigators. There have been major advances in our understanding of AML, including new knowledge about the molecular pathogenesis of AML, leading to an update of the disease classification, technological progress in genomic diagnostics and assessment of measurable residual disease, and the successful development of new therapeutic agents, such as FLT3, IDH1, IDH2, and BCL2 inhibitors. These advances have prompted this update that includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations.
The authors' abstract, as published at the source. Blood, 2022 · DOI ↗
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Field: Hematology
HematologyMedicine