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Blood· 2015Q1

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

David P. Steensma, Rafael Bejar, Siddhartha Jaiswal, R. Coleman Lindsley et al.

Short summary

Somatic mutations causing clonal expansion in aging hematopoietic cells, termed Clonal Hematopoiesis of Indeterminate Potential (CHIP), are common and increase risk for myeloid/lymphoid neoplasia and mortality, but most individuals with CHIP never develop MDS.

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Field: Hematology

HematologyMedicine