Science· 2019Q1
Clonal hematopoiesis in human aging and disease
- 1,131citations
- Q1SCImago
- 2019year
Short summary
Clonal hematopoiesis, where a single mutated stem cell generates a substantial proportion of blood cells, becomes highly prevalent in the elderly due to somatic mutations conferring a fitness advantage.
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Key points
- Clonal hematopoiesis arises from somatic mutations in stem cells that confer a fitness advantage.
- This process leads to a substantial proportion of blood cells originating from a single mutated stem cell.
- Clonal hematopoiesis is highly prevalent in the elderly population.
- It is associated with malignancies, non-malignant diseases of aging, and immune function changes.
AI-generated from the title and abstract; the full text is not read.
Abstract
As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmalignant diseases of aging, and its potential impact on immune function. Clonal hematopoiesis provides a glimpse into the process of mutation and selection that likely occurs in all somatic tissues.
The authors' abstract, as published at the source. Science, 2019 · DOI ↗
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Field: Hematology
HematologyMedicine