Signal Transduction and Targeted Therapy· 2020Q1· Review
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
- 1,143citations
- Q1SCImago
- 2020year
Short summary
Epigenetic changes, altered transport, regulated cell death, and the tumor microenvironment drive sorafenib resistance in late-stage hepatocellular carcinoma (HCC).
AI-generated from the title and abstract; the full text is not read.
Key points
- Sorafenib resistance is a growing challenge in treating late-stage HCC.
- Epigenetics, transport processes, regulated cell death, and the tumor microenvironment are implicated in resistance.
- Understanding these mechanisms is crucial for developing strategies to improve HCC treatment efficacy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC), sorafenib is currently an effective first-line therapy. Unfortunately, the development of drug resistance to sorafenib is becoming increasingly common. This study aims to identify factors contributing to resistance and ways to mitigate resistance. Recent studies have shown that epigenetics, transport processes, regulated cell death, and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression. This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients.
The authors' abstract, as published at the source. Signal Transduction and Targeted Therapy, 2020 · DOI ↗
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Field: Hepatology
HepatologyMedicine