Journal of Cell Science· 2013Q2
E-cadherin–integrin crosstalk in cancer invasion and metastasis
- 620citations
- Q2SCImago
- 2013year
Short summary
Tumor cells dynamically regulate crosstalk between E-cadherin cell-cell adhesions and integrin cell-matrix contacts to control invasion and metastasis.
AI-generated from the title and abstract; the full text is not read.
Key points
- Tumor progression involves loss of E-cadherin function and increased cell motility.
- Invasion and metastasis depend on coordinated regulation of E-cadherin and integrin adhesions.
- Crosstalk between cell-cell and cell-matrix adhesions is dynamic and responds to the tumor microenvironment.
- Key regulators of this crosstalk include Src, FAK, ILK, and Rho family GTPases.
AI-generated from the title and abstract; the full text is not read.
Abstract
E-cadherin is a single-pass transmembrane protein that mediates homophilic cell-cell interactions. Tumour progression is often associated with the loss of E-cadherin function and the transition to a more motile and invasive phenotype. This requires the coordinated regulation of both E-cadherin-mediated cell-cell adhesions and integrin-mediated adhesions that contact the surrounding extracellular matrix (ECM). Regulation of both types of adhesion is dynamic as cells respond to external cues from the tumour microenvironment that regulate polarity, directional migration and invasion. Here, we review the mechanisms by which tumour cells control the cross-regulation between dynamic E-cadherin-mediated cell-cell adhesions and integrin-mediated cell-matrix contacts, which govern the invasive and metastatic potential of tumours. In particular, we will discuss the role of the adhesion-linked kinases Src, focal adhesion kinase (FAK) and integrin-linked kinase (ILK), and the Rho family of GTPases.
The authors' abstract, as published at the source. Journal of Cell Science, 2013 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Immunology and Allergy
Immunology and AllergyMedicine