Clinical Microbiology Reviews· 2015Q1· Review
Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management
- 5,131citations
- Q1SCImago
- 2015year
Short summary
Staphylococcus aureus is a leading cause of diverse human infections, with recent shifts towards increased healthcare-associated infections and community-acquired skin/soft tissue infections driven by resistant strains.
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Key points
- Staphylococcus aureus causes a wide spectrum of infections, including bacteremia, endocarditis, and osteoarticular, skin, and device-related infections.
- Epidemiological shifts show an increase in healthcare-associated infections and community-associated skin/soft tissue infections.
- Community-associated infections are often driven by strains with specific virulence factors and beta-lactam resistance.
- There is a notable lack of high-quality evidence to support many management strategies for S. aureus infections.
AI-generated from the title and abstract; the full text is not read.
Abstract
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.
The authors' abstract, as published at the source. Clinical Microbiology Reviews, 2015 · DOI ↗
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Field: Infectious Diseases
Infectious DiseasesMedicine