Indian Journal of Dermatology· 2017Q3· Review
Mycetoma: An update
- 114citations
- Q3SCImago
- 2017year
Short summary
Mycetoma, a chronic granulomatous infection of subcutaneous tissue, skin, and bones in tropical/subtropical areas, is characterized by swelling, sinus tracts, and granules, but accurate diagnosis via histopathology and microbiology is challenging and crucial due to distinct treatments for fungal (eumycetoma) and bacterial (actinomycetoma) causes.
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Key points
- Mycetoma is a chronic infection of subcutaneous tissue, skin, and bones characterized by swelling, sinus tracts, and granules.
- Etiological classification divides mycetoma into eumycetoma (fungal) and actinomycetoma (bacterial), requiring different treatments.
- Definitive diagnosis via histopathology and microbiology is mandatory but difficult.
- The disease is notoriously difficult to treat, with variable responses to standard antifungal and antibiotic therapies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult. Serological test exists but is not so reliable; however, molecular techniques to identify relevant antigens have shown promise. The disease is notoriously difficult to treat. Eumycetoma may be unresponsive to standard antifungal therapy. Actinomycetoma responds to antibiotic therapy, but prolonged treatment is necessary. This review focuses on the etiopathogenesis, clinical features, laboratory diagnosis, and treatment of mycetoma.
The authors' abstract, as published at the source. Indian Journal of Dermatology, 2017 · DOI ↗
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Field: Microbiology
MicrobiologyMedicine