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Kidney & Blood Pressure Research· 2014Q2

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

Ahmad Almilaji, Sabina Honisch, Guilai Liu, Bernat Elvira et al.

Short summary

Recombinant human Klotho protein significantly enhances Kv1.3 channel abundance and currents in cell membranes, an effect dependent on Klotho's beta-glucuronidase activity.

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Field: Nephrology

NephrologyMedicine