Kidney & Blood Pressure Research· 2017Q2· Review
Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes
- 1,407citations
- Q2SCImago
- 2017year
Short summary
Adipocytes and their secreted adipokines play a significant, yet often overlooked, role in promoting chronic inflammation and angiogenesis in patients undergoing peritoneal dialysis (PD), leading to peritoneum remodeling and ultrafiltration failure.
AI-generated from the title and abstract; the full text is not read.
Key points
- Chronic inflammation and angiogenesis are key complications in peritoneal dialysis (PD).
- Adipocytes in the deeper peritoneal tissue contribute to these processes.
- Adipokines secreted by adipocytes can promote or inhibit inflammation and angiogenesis.
- These factors coordinate to modulate neovascularization and inflammation in long-term PD.
AI-generated from the title and abstract; the full text is not read.
Abstract
Chronic inflammation and angiogenesis are the most common complications in patients undergoing maintenance peritoneal dialysis (PD), resulting in progressive peritoneum remolding and, eventually, utrafiltration failure. Contributing to the deeper tissue under the peritoneal membrane, adipocytes play a neglected role in this process. Some adipokines act as inflammatory and angiogenic promoters, while others have the opposite effects. Adipokines, together with inflammatory factors and other cytokines, modulate inflammation and neovascularization in a coordinated fashion. This review will also emphasize cellular regulators and their crosstalk in long-term PD. Understanding the molecular mechanism, targeting changes in adipocytes and regulating adipokine secretion will help extend therapeutic methods for preventing inflammation and angiogenesis in PD.
The authors' abstract, as published at the source. Kidney & Blood Pressure Research, 2017 · DOI ↗
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Field: Nephrology
NephrologyMedicine