International Journal of Cardiology· 2015Q1· Review
Regulation of uric acid metabolism and excretion
- 1,370citations
- Q1SCImago
- 2015year
Short summary
This review details the enzymatic pathways of purine degradation, culminating in uric acid formation, and highlights its emerging role in human disease, particularly cardiovascular conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Purines are vital for DNA, RNA, energy metabolism, and signaling.
- Humans are unique among mammals in excreting uric acid as the final purine catabolism product.
- Elevated serum uric acid is associated with increased disease severity, particularly cardiovascular disease.
- The review covers the enzymatic pathways from purine structure to uric acid formation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Purines perform many important functions in the cell, being the formation of the monomeric precursors of nucleic acids DNA and RNA the most relevant one. Purines which also contribute to modulate energy metabolism and signal transduction, are structural components of some coenzymes and have been shown to play important roles in the physiology of platelets, muscles and neurotransmission. All cells require a balanced quantity of purines for growth, proliferation and survival. Under physiological conditions the enzymes involved in the purine metabolism maintain in the cell a balanced ratio between their synthesis and degradation. In humans the final compound of purines catabolism is uric acid. All other mammals possess the enzyme uricase that converts uric acid to allantoin that is easily eliminated through urine. Overproduction of uric acid, generated from the metabolism of purines, has been proven to play emerging roles in human disease. In fact the increase of serum uric acid is inversely associated with disease severity and especially with cardiovascular disease states. This review describes the enzymatic pathways involved in the degradation of purines, getting into their structure and biochemistry until the uric acid formation.
The authors' abstract, as published at the source. International Journal of Cardiology, 2015 · DOI ↗
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Field: Nephrology
NephrologyMedicine