Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Short summary

Single-cell RNA sequencing of 4645 melanoma cells from 19 patients identified transcriptional heterogeneity in malignant cells, including distinct states associated with drug resistance (e.g., high MITF vs. low MITF/high AXL). The analysis also mapped tumor microenvironmental patterns and T cell exhaustion programs.

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