Clinical Cancer Research· 2014Q1
Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
- 662citations
- Q1SCImago
- 2014year
Short summary
HPV-positive and HPV-negative head and neck squamous cell carcinomas (HNSCC) show distinct genetic differences, including targetable mutations in FGFR and PI3K pathway genes, with HPV-positive tumors uniquely enriched for FGFR3 S249C mutations (17.6%) and KRAS mutations (5.8%).
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OtorhinolaryngologyMedicine