Journal of Clinical Oncology· 2015Q1· Review
Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma
- 1,241citations
- Q1SCImago
- 2015year
Short summary
Human papillomavirus (HPV) is the primary driver behind rising rates of a specific type of head and neck cancer globally. Understanding its epidemiology is crucial for developing interventions to reverse these trends.
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Key points
- HPV is the principal cause of increasing incidence of a subset of head and neck squamous cell cancers globally.
- Key epidemiological factors reviewed include incidence trends, HPV-attributable fraction, sex disparities, and latency.
- Prophylactic HPV vaccination and secondary prevention through screening are discussed as potential interventions.
- The identification of HPV as a necessary cause presents a rare opportunity for cancer prevention.
AI-generated from the title and abstract; the full text is not read.
Abstract
Human papillomavirus (HPV) is now established as the principal cause of an increase in incidence of a subset of head and neck squamous cell cancers (HNCs) in numerous geographic regions around the world. Further study of the epidemiology of HPV-positive HNC will be critical to the development and implementation of public health interventions to reverse these global incidence trends. Here, recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention through screening for oral HPV infection or seroreactivity to viral antigens. The identification of a single necessary cause for any cancer provides a rare and perhaps extraordinary opportunity for cancer prevention.
The authors' abstract, as published at the source. Journal of Clinical Oncology, 2015 · DOI ↗
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Field: Otorhinolaryngology
OtorhinolaryngologyMedicine