Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer

Short summary

Induction chemotherapy (IC) followed by chemoradiotherapy (CRT) did not improve overall survival (OS) compared to CRT alone in patients with N2 or N3 locally advanced head and neck squamous cell carcinoma (SCCHN). The study found no significant differences in OS (hazard ratio, 0.91; 95% CI, 0.59 to 1.41) after a minimum 30-month follow-up.

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