Neurology· 2014Q1
Defining the clinical course of multiple sclerosis
- 3,150citations
- Q1SCImago
- 2014year
Short summary
International MS experts have refined clinical disease phenotypes by incorporating disease activity (relapse rate and imaging) and progression, addressing limitations of 1996 descriptors that lacked objective correlates.
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Key points
- Refined clinical phenotypes for MS have been proposed by an international committee.
- New descriptors incorporate disease activity (relapse rate, imaging) and progression.
- The update addresses limitations of 1996 descriptors which lacked imaging and biological correlates.
- Strategies for future research to better define MS phenotypes are outlined.
AI-generated from the title and abstract; the full text is not read.
Abstract
Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.
The authors' abstract, as published at the source. Neurology, 2014 · DOI ↗
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Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine