International Journal of Molecular Sciences· 2020Q1
Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms
- 1,262citations
- Q1SCImago
- 2020year
Short summary
This review synthesizes current understanding of spinal cord injury (SCI) pathophysiology, detailing the cascade of destructive events and exploring neuroprotective, immunomodulatory, and neuro-regenerative therapies.
AI-generated from the title and abstract; the full text is not read.
Key points
- SCI involves a destructive cascade including ischemia, oxidative stress, inflammation, and apoptosis.
- Therapeutic strategies focus on neuroprotection and neuro-regeneration to reduce secondary damage and promote recovery.
- Curative success is limited by the complexity of SCI healing and protective mechanisms.
- Understanding these mechanisms is crucial for developing effective treatment modalities.
AI-generated from the title and abstract; the full text is not read.
Abstract
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ischemia, oxidative stress, inflammatory events, apoptotic pathways and locomotor dysfunctions. Many therapeutic strategies have been proposed to overcome neurodegenerative events and reduce secondary neuronal damage. Efforts have also been devoted in developing neuroprotective and neuro-regenerative therapies that promote neuronal recovery and outcome. Although varying degrees of success have been achieved, curative accomplishment is still elusive probably due to the complex healing and protective mechanisms involved. Thus, current understanding in this area must be assessed to formulate appropriate treatment modalities to improve SCI recovery. This review aims to promote the understanding of SCI pathophysiology, interrelated or interlinked multimolecular interactions and various methods of neuronal recovery i.e., neuroprotective, immunomodulatory and neuro-regenerative pathways and relevant approaches.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2020 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine