Journal of Clinical Investigation· 2013Q1
Myocardial ischemia-reperfusion injury: a neglected therapeutic target
- 2,333citations
- Q1SCImago
- 2013year
Short summary
Myocardial reperfusion, while crucial for treating heart attacks, paradoxically causes further heart muscle death (reperfusion injury) for which no effective therapy currently exists.
AI-generated from the title and abstract; the full text is not read.
Key points
- Reperfusion therapy for heart attacks can cause additional heart muscle damage.
- This 'reperfusion injury' is a significant cause of cardiomyocyte death.
- No effective therapies currently exist to prevent myocardial reperfusion injury.
- New therapeutic strategies are being investigated to improve outcomes in MI patients.
AI-generated from the title and abstract; the full text is not read.
Abstract
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
The authors' abstract, as published at the source. Journal of Clinical Investigation, 2013 · DOI ↗
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Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine