Nutrients· 2013Q1· Review
Vitamin D and Immune Function
- 1,133citations
- Q1SCImago
- 2013year
Short summary
Vitamin D modulates both innate and adaptive immune cells, promoting a tolerogenic immune status and showing beneficial effects in autoimmunity, particularly type 1 diabetes.
AI-generated from the title and abstract; the full text is not read.
Key points
- Vitamin D metabolizing enzymes and receptors are present in various immune cells.
- Vitamin D promotes a tolerogenic immunological status.
- In vitro data show vitamin D modulates innate immune cells.
- In vivo studies indicate beneficial effects of vitamin D on immune function, particularly in autoimmunity.
- The review focuses on vitamin D's effects on the immune system and autoimmune diseases like type 1 diabetes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.
The authors' abstract, as published at the source. Nutrients, 2013 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Pathology and Forensic Medicine
Pathology and Forensic MedicineMedicine