The Lancet· 2016
Schizophrenia
- 1,858citations
- 2016year
Short summary
Schizophrenia arises from disrupted brain development due to genetic/environmental factors, involving dopaminergic dysfunction and broader circuit abnormalities.
AI-generated from the title and abstract; the full text is not read.
Key points
- Schizophrenia originates from disrupted brain development, caused by genetic or environmental factors.
- Dopaminergic neurotransmission dysfunction contributes to psychotic symptoms.
- Widespread involvement of other brain areas and circuits, including synaptic function and interneurons, is suggested.
- Current treatments are inadequate, necessitating more effective therapies and service delivery.
AI-generated from the title and abstract; the full text is not read.
Abstract
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous--but so are the challenges.
The authors' abstract, as published at the source. The Lancet, 2016 · DOI ↗
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Field: Psychiatry and Mental health
Psychiatry and Mental healthMedicine