Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis

Short summary

Network meta-analysis of 402 trials (53,463 participants) found all 32 antipsychotics reduced schizophrenia symptoms more than placebo, with clozapine showing the largest effect on overall symptoms (SMD -0.89). Differences in efficacy were gradual, but side-effect differences were more pronounced.

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