BMC Complementary Medicine and Therapies· 2026Q1
Vitis vinifera Yapraklarının Fitokimyası ve İn Vitro Biyoaktivitelerinde Hasat Zamanına Bağlı Değişimler
Harvest-Time–Dependent variations in phytochemistry and in vitro bioactivities of Vitis vinifera Leaves
- 0atıf
- Q1SCImago
- 2026yıl
Kısa özet
Mayıs ayında hasat edilen üzüm yaprakları, Mart veya Eylül ayında hasat edilenlere kıyasla anlamlı derecede daha yüksek seviyelerde biyoaktif bileşikler (polifenoller, flavonoidler, tanenler) ve üstün in vitro antioksidan, antidiyabetik, anti-Alzheimer, anti-inflamatuar, anti-artritik ve sitotoksik aktivite göstermiştir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Mayıs ayında hasat edilen üzüm yaprakları en yüksek klorofil, polifenol, flavonoid ve tanen seviyelerine sahipti.
- HPLC analizi, Mayıs ekstraktlarında fenolik ve flavonoid bileşiklerin daha fazla biriktiğini ortaya koymuştur.
- Mayıs ekstraktı, üstün antioksidan ve radikal süpürücü aktivite sergilemiştir.
- Mayıs ayında hasat edilen yapraklar, in vitro antidiyabetik, anti-Alzheimer, anti-inflamatuar, anti-artritik ve sitotoksik etkilerde en güçlü sonuçları vermiştir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Abstract Background Vitis vinifera L. leaves are rich in bioactive phytochemicals, but their composition and biological activities may vary considerably with harvest time. This study investigated harvest-dependent changes in the phytochemical profile and in vitro biological activities of grape leaves. Methods Methanolic extracts of V. vinifera leaves collected in March, May, and September were evaluated for photosynthetic pigments, total polyphenols, flavonoids, and tannins. HPLC analysis was used to characterize individual phenolic and flavonoid constituents, while major compounds were isolated and structurally identified. The extracts were further assessed for antioxidant and radical-scavenging, antidiabetic, anti-Alzheimer’s, anti-inflammatory, anti-arthritic, and cytotoxic activities. Results Harvest time markedly affected the phytochemical composition and biological activities of the leaves. The May-harvested leaves showed the highest levels of total chlorophyll, polyphenols, flavonoids, and tannins, whereas carotenoids were comparatively higher in the September and March samples. HPLC analysis revealed greater accumulation of phenolic and flavonoid constituents in the May extract, with chlorogenic acid, rosmarinic acid, gallic acid, and naringenin among the predominant compounds. Consistently, the May extract exhibited the strongest antioxidant and radical-scavenging activities and showed superior inhibitory effects in the antidiabetic, anti-Alzheimer’s, anti-inflammatory, anti-arthritic, and cytotoxic assays compared with the other harvest periods. Conclusion Harvest time substantially influences the accumulation of bioactive constituents and the in vitro biological potential of V. vinifera leaves. Among the investigated periods, May appeared to be the most favorable harvest time for obtaining grape leaves enriched in bioactive phytochemicals with promising biological activities, supporting their potential valorization as a value-added viticultural by-product.
Yazarların özeti; kaynağından alınmıştır. BMC Complementary Medicine and Therapies, 2026 · DOI ↗
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