RSC Advances· 2018Q1· Review
A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing
- 890citations
- Q1SCImago
- 2018year
Short summary
Chitosan-based hydrogels offer a promising platform for advanced wound healing, functioning as both protective dressings and drug delivery systems for agents like antibacterials and growth factors.
AI-generated from the title and abstract; the full text is not read.
Key points
- Chitosan hydrogels provide a moist wound environment and protect against infection.
- They possess inherent properties like biodegradability, biocompatibility, and antimicrobial activity.
- These hydrogels can be used as drug delivery systems for antibacterial agents, growth factors, and stem cells.
- Modifying chitosan hydrogels with other polymers enhances their effectiveness for various wound types.
AI-generated from the title and abstract; the full text is not read.
Abstract
Functional active wound dressings are expected to provide a moist wound environment, offer protection from secondary infections, remove wound exudate and accelerate tissue regeneration, as well as to improve the efficiency of wound healing. Chitosan-based hydrogels are considered as ideal materials for enhancing wound healing owing to their biodegradable, biocompatible, non-toxic, antimicrobial, biologically adhesive, biological activity and hemostatic effects. Chitosan-based hydrogels have been demonstrated to promote wound healing at different wound healing stages, and also can alleviate the factors against wound healing (such as excessive inflammatory and chronic wound infection). The unique biological properties of a chitosan-based hydrogel enable it to serve as both a wound dressing and as a drug delivery system (DDS) to deliver antibacterial agents, growth factors, stem cells and so on, which could further accelerate wound healing. For various kinds of wounds, chitosan-based hydrogels are able to promote the effectiveness of wound healing by modifying or combining with other polymers, and carrying different types of active substances. In this review, we will take a close look at the application of chitosan-based hydrogels in wound dressings and DDS to enhance wound healing.
The authors' abstract, as published at the source. RSC Advances, 2018 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine