Biomedicine & Pharmacotherapy· 2019Q1· Review
Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing
- 1,029citations
- Q1SCImago
- 2019year
Short summary
This review details the molecular cascades and factors contributing to delayed diabetic wound healing, highlighting potential molecular targets and recent therapeutic advancements.
AI-generated from the title and abstract; the full text is not read.
Key points
- Diabetic wounds heal with significant delay, posing a critical research challenge.
- Molecular cascades involving cytokines, growth factors, and other factors are responsible for impaired healing.
- The review identifies key molecular targets for therapeutic intervention.
- Recent advancements and clinical trials in wound healing strategies are discussed.
AI-generated from the title and abstract; the full text is not read.
Abstract
Wound management in diabetic patient is of an extreme clinical and social concern. The delayed and impaired healing makes it more critical for research focus. The research on impaired healing process is proceeding hastily evident by new therapeutic approaches other than conventional such as single growth factor, dual growth factor, skin substitutes, cytokine stimulators, cytokine inhibitors, matrix metalloproteinase inhibitors, gene and stem cell therapy, extracellular matrix and angiogenesis stimulators. Although numerous studies are available that support delayed wound healing in diabetes but detailed mechanistic insight including factors involved and their role still needs to be revealed. This review mainly focuses on the molecular cascades of cytokines (with growth factors) and erstwhile factors responsible for delayed wound healing, molecular targets and recent advancements in complete healing and its cure. Present article briefed recent pioneering information on possible molecular targets and treatment strategies including clinical trials to clinicians and researchers working in similar area.
The authors' abstract, as published at the source. Biomedicine & Pharmacotherapy, 2019 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine