Advanced Science· 2026Q1
Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling
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- Q1SCImago
- 2026year
Short summary
A novel design framework uses 3D printing to integrate thermal and electrical components into miniaturized, soft brain implants for focal brain cooling and ECoG recording.
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Key points
- A new design framework combines 3D printing with silicones and electronic components for implant fabrication.
- The integrated implants enable simultaneous focal brain cooling and ECoG recording.
- The system achieved rapid, stable, and localized hypothermia.
- In a rodent epilepsy model, hypothermia induced by the implant suppressed seizure-like activity.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT The limitations of electrical neuromodulation are driving the development of neuroprosthetic systems enhanced with complementary modalities. A key technological challenge however remains the integration of the necessary hardware components (optical, thermal, fluidic, electrical) into miniaturized implants. Here we present a design framework, inspired by fast prototyping, that promises to reduce the complexity, fabrication time, and device bulk of multimodal neural interface systems. By combining extrusion‐based 3D printing of silicones and discrete electronic components, we integrated thermal neuromodulation and electrical recording capabilities in soft packages suitable for placement on the cortical surface of rodents. When linked to an autonomous auxiliary driver unit, these packages establish rapid, stable and localized hypothermia together with ElectroCorticoGraphy (ECoG) recording. In a rodent model of epilepsy (4‐aminopyridine), we demonstrate hypothermia‐induced suppression of seizure‐like activity. Our approach may advance the clinical translation of focal hypothermia as an alternative therapy for drug‐resistant focal epilepsies.
The authors' abstract, as published at the source. Advanced Science, 2026 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience