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Journal of the American Society of Nephrology· 2015Q1

IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury

Carmen Lefaucheur, Denis Viglietti, Carol Bentlejewski, Jean–Paul Duong Van Huyen et al.

Short summary

Donor-specific antibodies (DSA) of the IgG3 subclass are linked to acute antibody-mediated rejection (aABMR) and faster kidney allograft failure, while IgG4 subclass DSA are associated with subclinical ABMR and later, chronic injury.

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Field: Transplantation

TransplantationMedicine