The American Journal of Sports Medicine· 2013Q1
The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis
- 392citations
- Q1SCImago
- 2013year
Short summary
Platelet-rich plasma (PRP) treatment of osteoarthritis (OA) joint tissues significantly reduced the expression of MMP-13 (a key enzyme in cartilage breakdown) in synoviocytes and increased hyaluronan synthase-2 (HAS-2) expression, suggesting enhanced endogenous hyaluronan production, compared to high molecular weight hyaluronan (HA) alone.
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