Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

Short summary

Kynurenine metabolites, derived from tryptophan breakdown, are crucial regulators of host-microbiome signaling, immune responses, and neuronal activity. Their accumulation in the brain is linked to depression and schizophrenia, but can be reduced by exercise-induced clearance in skeletal muscle.

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