JCI Insight· 2020Q1

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

Tiffany Thomas, Davide Stefanoni, Julie A. Reisz, Travis Nemkov et al.

604citations
Q1SCImago
2020year

Short summary

COVID-19 infection significantly alters tryptophan metabolism via the kynurenine pathway and dysregulates nitrogen and carbon homeostasis, increasing circulating free fatty acids and glucose, with these changes correlating to IL-6 levels and markers of renal dysfunction.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience