Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

Short summary

The kynurenine pathway (KP) degrades approximately 95% of dietary tryptophan, with the liver handling 90% via TDO and extrahepatic tissues playing a larger role during immune activation via IDO. This pathway produces immunoregulatory and neuroactive metabolites, and its dysregulation is implicated in various diseases.

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