Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

Short summary

A systematic review of 18 studies found consistent evidence that psychosocial stressors increase microglial activity (Iba-1 levels) by 20-200% in the hippocampus and frequently in the prefrontal cortex, nucleus accumbens, amygdala, and paraventricular nucleus, with effects seen from early life to adulthood.

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