Frontiers in Cellular Neuroscience· 2014Q2
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
- 482citations
- Q2SCImago
- 2014year
Short summary
Pro-inflammatory cytokines, when overproduced, can damage the central nervous system and impair neuroplasticity, with brain-derived neurotrophic factor (BDNF) emerging as a key mediator in this detrimental process.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pro-inflammatory cytokines play a role in immune-central nervous system communication.
- Pathological overproduction of pro-inflammatory cytokines can damage the central nervous system.
- This damage can lead to deficits in neuroplasticity.
- Brain-derived neurotrophic factor (BDNF) is implicated as a key mediator linking inflammation and neuroplasticity deficits.
AI-generated from the title and abstract; the full text is not read.
Abstract
Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.
The authors' abstract, as published at the source. Frontiers in Cellular Neuroscience, 2014 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience