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Proceedings of the National Academy of Sciences· 2013Q1

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Taisuke Kadoshima, Hideya Sakaguchi, Tokushige Nakano, Mika Soen et al.

Short summary

Human ES cell-derived cortical tissue spontaneously self-organizes axial polarity, forms an inside-out neuronal layer pattern, and exhibits species-specific progenitor dynamics, recapitulating early human fetal cortex development.

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Field: Cellular and Molecular Neuroscience

Cellular and Molecular NeuroscienceNeuroscience