Cell· 2017Q1
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
- 1,006citations
- Q1SCImago
- 2017year
Short summary
Researchers developed a noninvasive method to stimulate deep brain neurons using multiple, high-frequency electric fields that interfere to create a lower-frequency envelope, enabling targeted neural activation without affecting overlying tissues.
AI-generated from the title and abstract; the full text is not read.
Key points
- Developed a noninvasive temporal interference (TI) stimulation method for deep brain activation.
- TI uses multiple high-frequency electric fields whose interference creates a lower-frequency envelope to recruit neurons.
- Validated TI in modeling, physics experiments, and living mouse brains.
- Successfully stimulated deep hippocampal neurons without affecting overlying cortex in mice.
- Demonstrated steerable motor pattern evocation by adjusting electrode currents.
AI-generated from the title and abstract; the full text is not read.
Abstract
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
The authors' abstract, as published at the source. Cell, 2017 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience