International Journal of Dermatology· 2026Q1· Review
What Is Pediatric Melanoma? Clinical and Genomic Features and the Role of Next‐Generation Sequencing in Tumor Classification
- 1citations
- Q1SCImago
- 2026year
Short summary
Pediatric melanoma, though rare, presents diagnostic challenges due to overlapping features with benign tumors, but advances in genomic studies are clarifying its subtypes and genetic drivers.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pediatric melanoma is rare and diagnostically challenging due to overlapping features with benign melanocytic tumors.
- Epidemiologic and genomic studies are providing insights into the causes and genetic alterations of pediatric melanocytic tumors.
- The review covers environmental, host, and genetic factors for major pediatric melanoma subtypes.
- Key molecular biomarkers and a diagnostic approach integrating molecular data are presented.
AI-generated from the title and abstract; the full text is not read.
Abstract
Pediatric melanoma is rare and often poses diagnostic challenges because benign and malignant melanocytic tumors in children can share overlapping clinicopathologic features. Epidemiologic and genomic studies have provided important insights into the etiology of pediatric melanocytic tumors and the genetic alterations associated with malignant transformation. This review summarizes environmental, host, and genetic factors associated with the development of the major pediatric melanoma subtypes, including Spitz melanoma, low-cumulative solar damage (superficial spreading) melanoma, melanoma arising in congenital melanocytic nevi, and melanoma arising in blue nevi. It also highlights key molecular biomarkers associated with pediatric melanoma and presents a diagnostic approach to atypical pediatric melanocytic tumors that illustrates how molecular data can be integrated into tumor classification.
The authors' abstract, as published at the source. International Journal of Dermatology, 2026 · DOI ↗
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Field: Oncology
OncologyMedicine