Physiological Reviews· 2014Q1· Review
Regulation and Function of Adult Neurogenesis: From Genes to Cognition
- 626citations
- Q1SCImago
- 2014year
Short summary
Adult neurogenesis in the hippocampus, a process where new neurons arise from local stem cells and integrate into the dentate gyrus, is a unique model for linking molecular, cellular, and behavioral neuroscience.
AI-generated from the title and abstract; the full text is not read.
Key points
- Adult neurogenesis occurs in the hippocampus, originating from local neural stem cells.
- New neurons undergo several maturation stages before integrating into the dentate gyrus network.
- The process is regulated by both extrinsic and intrinsic factors.
- Neurogenesis links molecular, cellular, and behavioral scales of neuroscience.
AI-generated from the title and abstract; the full text is not read.
Abstract
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. This review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. The increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.
The authors' abstract, as published at the source. Physiological Reviews, 2014 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience