Science· 2014Q1
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- 1,051citations
- Q1SCImago
- 2014year
Short summary
Young blood factors can rejuvenate the aging mouse brain by promoting vascular remodeling, increasing neurogenesis, and improving cognitive function.
AI-generated from the title and abstract; the full text is not read.
Key points
- Young blood factors induce vascular remodeling in the aging mouse brain.
- These factors increase neurogenesis and improve olfactory discrimination.
- The protein GDF11 is identified as a key factor capable of improving cerebral vasculature and neurogenesis.
- Restoring the neurogenic niche counters age-related cognitive decline.
AI-generated from the title and abstract; the full text is not read.
Abstract
In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.
The authors' abstract, as published at the source. Science, 2014 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience