Science· 2016Q1
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
- 1,202citations
- Q1SCImago
- 2016year
Short summary
Single-cell RNA sequencing of over 5000 cells revealed 13 distinct oligodendrocyte populations in the mouse CNS, challenging the view of them as a homogeneous cell type.
AI-generated from the title and abstract; the full text is not read.
Key points
- Identified 13 distinct oligodendrocyte populations from mouse juvenile and adult CNS using single-cell RNA sequencing.
- Found regional enrichment of mature oligodendrocyte subsets in the adult brain.
- Detected newly formed oligodendrocytes in adults that responded to motor learning.
- Discovered a second Pdgfra(+) population along blood vessels, distinct from precursor cells.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra(+) population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience