Science· 2020Q1
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
- 503citations
- Q1SCImago
- 2020year
Short summary
Plasma from exercised aged mice, enriched with the liver-derived enzyme Gpld1, transferred exercise's benefits for neurogenesis and cognition to sedentary aged mice.
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Key points
- Plasma from exercised aged mice improved neurogenesis and cognition in sedentary aged mice.
- The liver-derived enzyme Gpld1 increased in blood after exercise and correlated with improved cognition.
- Elevated Gpld1 levels in aged mice reversed age-related cognitive and regenerative impairments.
- Gpld1 acts via a liver-to-brain axis, influencing signaling cascades downstream of GPI-anchored substrate cleavage.
AI-generated from the title and abstract; the full text is not read.
Abstract
Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age.
The authors' abstract, as published at the source. Science, 2020 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience