Science· 2012Q1
Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair
- 541citations
- Q1SCImago
- 2012year
Short summary
Astrocytes in the mouse CNS are restricted to spatial domains based on their embryonic origin and do not migrate to compensate for injury-induced depletion in adjacent regions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Astrocytes in the mouse CNS are allocated to specific spatial domains based on their embryonic origin.
- These astrocyte domains are stable throughout life and do not undergo secondary tangential migration.
- Depletion of astrocytes in a specific spinal cord region resulted in impaired motor neuron synaptogenesis.
- Astrocytes from adjacent regions did not migrate to compensate for the depleted domain, highlighting limitations in repair.
AI-generated from the title and abstract; the full text is not read.
Abstract
Astrocytes, the most abundant cell population in the central nervous system (CNS), are essential for normal neurological function. We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone. These domains remain stable throughout life without evidence of secondary tangential migration, even after acute CNS injury. Domain-specific depletion of astrocytes in ventral spinal cord resulted in abnormal motor neuron synaptogenesis, which was not rescued by immigration of astrocytes from adjoining regions. Our findings demonstrate that region-restricted astrocyte allocation is a general CNS phenomenon and reveal intrinsic limitations of the astroglial response to injury.
The authors' abstract, as published at the source. Science, 2012 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience