Journal of Pineal Research· 2015Q1

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Lucien C. Manchester, Ana Coto‐Montes, José Antonio Boga, Lars Peter Holst Andersen et al.

949citations
Q1SCImago
2015year

Short summary

This paper hypothesizes that melatonin's original and primary function, emerging 3.5-3.2 billion years ago in cyanobacteria, was as an antioxidant to counteract toxic free radicals produced by photosynthesis.

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Field: Endocrine and Autonomic Systems

Endocrine and Autonomic SystemsNeuroscience