Science· 2018Q1
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
- 809citations
- Q1SCImago
- 2018year
Short summary
Up to 81.7% of baboon protein-coding genes exhibit daily rhythmic expression across neural and peripheral tissues, revealing a new layer of functional specialization beyond tissue-specific gene expression.
AI-generated from the title and abstract; the full text is not read.
Key points
- Up to 81.7% of baboon protein-coding genes display daily rhythmic expression.
- Rhythmic gene expression provides functional specialization in addition to tissue-specific expression.
- Ubiquitously expressed genes show tissue-specific rhythmic expression patterns.
- Peak gene expression phases cluster around dawn and dusk, with a quiescent period in early night.
- Temporal organization differs between central/peripheral tissues and diurnal/nocturnal animals.
AI-generated from the title and abstract; the full text is not read.
Abstract
(baboon). Genomic transcription was highly rhythmic, with up to 81.7% of protein-coding genes showing daily rhythms in expression. In addition to tissue-specific gene expression, the rhythmic transcriptome imparts another layer of functional specialization. Most ubiquitously expressed genes that participate in essential cellular functions exhibit rhythmic expression in a tissue-specific manner. The peak phases of rhythmic gene expression clustered around dawn and dusk, with a "quiescent period" during early night. Our findings also unveil a different temporal organization of central and peripheral tissues between diurnal and nocturnal animals.
The authors' abstract, as published at the source. Science, 2018 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience