Science· 2013Q1
Circadian Gene <i>Bmal1</i> Regulates Diurnal Oscillations of Ly6C <sup>hi</sup> Inflammatory Monocytes
- 648citations
- Q1SCImago
- 2013year
Short summary
The circadian gene Bmal1 controls diurnal variations in Ly6C hi inflammatory monocytes, impacting their trafficking to inflammation sites and protection against Listeria monocytogenes.
AI-generated from the title and abstract; the full text is not read.
Key points
- Ly6C hi inflammatory monocytes exhibit diurnal variations in trafficking to inflammation sites.
- The circadian gene Bmal1 regulates these diurnal oscillations.
- Deletion of Bmal1 in myeloid cells disrupts monocyte cycling and increases chemokine expression.
- Disrupted Bmal1 function predisposes mice to inflammatory pathologies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Circadian clocks have evolved to regulate physiologic and behavioral rhythms in anticipation of changes in the environment. Although the molecular clock is present in innate immune cells, its role in monocyte homeostasis remains unknown. Here, we report that Ly6C(hi) inflammatory monocytes exhibit diurnal variation, which controls their trafficking to sites of inflammation. This cyclic pattern of trafficking confers protection against Listeria monocytogenes and is regulated by the repressive activity of the circadian gene Bmal1. Accordingly, myeloid cell-specific deletion of Bmal1 induces expression of monocyte-attracting chemokines and disrupts rhythmic cycling of Ly6C(hi) monocytes, predisposing mice to development of pathologies associated with acute and chronic inflammation. These findings have unveiled a critical role for BMAL1 in controlling the diurnal rhythms in Ly6C(hi) monocyte numbers.
The authors' abstract, as published at the source. Science, 2013 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience