Nature Communications· 2019Q1
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
- 732citations
- Q1SCImago
- 2019year
Short summary
Genome-wide association analyses in 697,828 individuals identified 351 genetic loci linked to chronotype (being a morning person), a 14-fold increase from previous findings.
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Key points
- Identified 351 genetic loci associated with chronotype in 697,828 individuals.
- Individuals with the most 'morningness' alleles sleep 25 minutes earlier than those with the fewest.
- Associated loci are enriched for circadian regulation, cAMP, glutamate, and insulin signaling pathways.
- Being a morning person is causally linked to better mental health, but not BMI or Type 2 diabetes risk.
AI-generated from the title and abstract; the full text is not read.
Abstract
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
The authors' abstract, as published at the source. Nature Communications, 2019 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience