Journal of Clinical Investigation· 2017Q1· Review
The aging clock: circadian rhythms and later life
- 617citations
- Q1SCImago
- 2017year
Short summary
Circadian rhythms, crucial for physiology and behavior, change significantly with age, leading to fragmented sleep/wake patterns and potential health detriments.
AI-generated from the title and abstract; the full text is not read.
Key points
- Circadian rhythms influence most physiological and behavioral processes.
- The biological clock regulating circadian rhythms changes dynamically over the lifespan.
- Aging is associated with significant changes in rhythmic activities like sleep/wake patterns, often leading to fragmentation.
- Disruptions in circadian rhythms are linked to negative health outcomes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in the vast majority of species on Earth. The biological clockwork that regulates these rhythms is dynamic over the lifespan: rhythmic activities such as sleep/wake patterns change markedly as we age, and in many cases they become increasingly fragmented. Given that prolonged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how our biological clocks change with age may create valuable opportunities to improve health and longevity for an aging global population. In this Review, we synthesize key findings from the study of circadian rhythms in later life, identify patterns of change documented to date, and review potential physiological mechanisms that may underlie these changes.
The authors' abstract, as published at the source. Journal of Clinical Investigation, 2017 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience