International Journal of Molecular Sciences· 2013Q1
Melatonin: Buffering the Immune System
- 726citations
- Q1SCImago
- 2013year
Short summary
Melatonin acts as an immune buffer, stimulating immune responses under basal or suppressed conditions and reducing inflammation during exacerbated immune responses.
AI-generated from the title and abstract; the full text is not read.
Key points
- Melatonin exhibits a dual role in immune modulation, acting as a buffer.
- It stimulates immune responses under basal or immunosuppressive conditions.
- It reduces inflammation during exacerbated immune responses, like acute inflammation.
- The review covers clinical relevance in infection, autoimmunity, vaccination, and immunosenescence.
AI-generated from the title and abstract; the full text is not read.
Abstract
Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2013 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience